Studi Efek Klozapin pada Leukosit, Trombosit, dan Gula Darah pada Pasien Skizofrenia di RSJ Sambang Lihum Tahun 2024
DOI:
https://doi.org/10.66914/6k0qe154Keywords:
Klozapin, skizofrenia, leukosit, trombosit, gula darah, purposive sampling., Clozapine, schizophrenia, leukocytes, platelets, blood sugar, purposive sampling.Abstract
Klozapin adalah antipsikotik atipikal yang sering digunakan untuk pasien skizofrenia yang tidak merespons terapi lain. Namun, penggunaannya bisa menyebabkan efek samping pada kadar leukosit, trombosit, dan gula darah. Penelitian ini bertujuan untuk menganalisis pengaruh klozapin terhadap ketiga parameter tersebut pada pasien skizofrenia di RSJ Sambang Lihum selama tahun 2024. Penelitian ini bersifat deskriptif dengan pengumpulan data retrospektif menggunakan survei deskriptif dan metode total sampling Diharapkan hasil penelitian ini dapat memberikan informasi tentang dampak klozapin dan membantu tenaga kesehatan dalam memantau serta mengelola efek samping pada pasien yang menerima terapi ini.
Keywords: Clozapine, schizophrenia, leukocytes, platelets, blood sugar, purposive sampling.
Abstract
Clozapine is an atypical antipsychotic commonly used for schizophrenia patients who do not respond to other treatments. However, its use can cause side effects on leukocyte, platelet, and blood glucose levels. This study aims to analyze the effects of clozapine on these parameters in schizophrenia patients at RSJ Sambang Lihum during 2024. The study is descriptive, using retrospective data collection with a descriptive survey method and purposive sampling in a cross-sectional approach. It is hoped that this research will provide information on the impact of clozapine and help healthcare professionals monitor and manage side effects in patients receiving this therapy.
Kata kunci: Klozapin, skizofrenia, leukosit, trombosit, gula darah, purposive sampling.
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References
Audia, S., Mahévas, M., Samson, M., Godeau, B., & Bonnotte, B. (2017). Pathogenesis of immune thrombocytopenia. Autoimmunity reviews, 16(6), 620-632.
Cernea, S., Dima, L., Correll, C. U., & Manu, P. (2020). Pharmacological management of glucose dysregulation in patients treated with second-generation antipsychotics. Drugs, 80(17), 1763-1781.
Ellenbroek, B. A., & Cesura, A. M. (2015). Antipsychotics and the dopamine–serotonin connection. Small Molecule Therapeutics for Schizophrenia, 1-49.
Grajales, D., Ferreira, V., & Valverde, Á. M. (2019). Second-generation antipsychotics and dysregulation of glucose metabolism: beyond weight gain. Cells, 8(11), 1336.
Himmerich, H., Minkwitz, J., & C Kirkby, K. (2015). Weight gain and metabolic changes during treatment with antipsychotics and antidepressants. Endocrine, Metabolic & Immune Disorders-Drug Targets (Formerly Current Drug Targets-Immune, Endocrine & Metabolic Disorders), 15(4), 252-260.
Hollingworth, S. A., Winckel, K., Saiepour, N., Wheeler, A. J., Myles, N., & Siskind, D. (2018). Clozapine-related neutropenia, myocarditis and cardiomyopathy adverse event reports in Australia 1993–2014. Psychopharmacology, 235, 1915-1921.
Kementerian Kesehatan RI (2013). Riset Kesehatan Dasar. Riskesdas 2013. Jakarta: Badan Penelitian dan Pengembangan Kesehatan
Kusuma, I. Y., Oktaviani, P., Fasha, A. A., & Apriliansa, E. P. (2020). Gambaran Kadar Glukosa, Leukosit dan Trombosit Pasien Schizophrenia Rawat Jalan dengan Terapi Clozapine di RSUD Banyumas, Indonesia. Open Journal of Pharmacopolium, 3(3), 121-130.
Kusuma, I. Y., Oktaviani, P., Oktavia, G. A., Fauqina, A. A., & Piri, J. P. A. (2021). Pengaruh Penggunaan Clozapin Terhadap Kadar Leukosit, Trombosit, dan Glukosa Darah Pada Pasien Skizofrenia di RSU Banyumas. Jurnal Farmasi Sains dan Praktis, 7(3), 374-383.
Lally, J., & Flanagan, R. J. (2016). Severe neutropenia and agranulocytosis. In Life-Threatening Effects of Antipsychotic Drugs (pp. 105-148). Academic Press.
Paribello, P., Manchia, M., Zedda, M., Pinna, F., & Carpiniello, B. (2021). Leukocytosis Associated with Clozapine Treatment: A Case Series and Systematic Review of the Literature. Medicina, 57(816), 1-12.
Prasetya, H. R., Nuryati, A., Murtiningrum, S., & Ramadhani, R. W. (2024). Leukositosis pada Pasien Skizofrenia yang Mendapat Terapi Obat Antipsikotik. Jurnal Kolaboratif Sains, 7(2), 958-966.
Rakesh, K. R. M., Innamuri, R. T., & Kattula, D. (2022). Clozapine and Thrombocytopenia: Case Report & Literature Review. Indian J Psychiatry, 64(3), 1-10.
Rizki, N. A., Watulingas, J. R., & Asnawati, A. (2023). Analisis Perbedaan Nilai Setiap Siklus dalam Penelitian Tindakan Kelas Menggunakan Uji Wilcoxon. Buana Matematika: Jurnal Ilmiah Matematika Dan Pendidikan Matematika, 13(2), 169-180.
Yuen, J. W., Kim, D. D., Procyshyn, R. M., Panenka, W. J., Honer, W. G., & Barr, A. M. (2021). A focused review of the metabolic side-effects of clozapine. Frontiers in endocrinology, 12, 609240.
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Copyright (c) 2026 Muhammad Jafar, Muhammad Fauzi, Nily Su’aida (Author)

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Muhammad Jafar

